Knockin mouse models demonstrate differential contributions of synaptotagmin-1 and -2 as receptors for botulinum neurotoxins

Botulinum neurotoxins (BoNTs) are the most potent toxins known and are also utilized to treat a wide range of disorders including muscle spasm, overactive bladder, and pain. BoNTs’ ability to target neurons determines their specificity, potency, and therapeutic efficacy. Homologous synaptic vesicle...

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Detalles Bibliográficos
Autores principales: Thaker, Hatim, Zhang, Jie, Miyashita, Shin-Ichiro, Cristofaro, Vivian, Park, SunHyun, Hashemi Gheinani, Ali, Sullivan, Maryrose P., Adam, Rosalyn M., Dong, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553082/
https://www.ncbi.nlm.nih.gov/pubmed/34662366
http://dx.doi.org/10.1371/journal.ppat.1009994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553082/
https://www.ncbi.nlm.nih.gov/pubmed/34662366
http://dx.doi.org/10.1371/journal.ppat.1009994

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