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Discrete mechanical model of lamellipodial actin network implements molecular clutch mechanism and generates arcs and microspikes

Mechanical forces, actin filament turnover, and adhesion to the extracellular environment regulate lamellipodial protrusions. Computational and mathematical models at the continuum level have been used to investigate the molecular clutch mechanism, calculating the stress profile through the lamellip...

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Detalles Bibliográficos
Autores principales: Rutkowski, David M., Vavylonis, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553091/
https://www.ncbi.nlm.nih.gov/pubmed/34662335
http://dx.doi.org/10.1371/journal.pcbi.1009506