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Microbiota-Host-Irinotecan Axis: A New Insight Toward Irinotecan Chemotherapy
Irinotecan (CPT11) and its active metabolite ethyl-10-hydroxy-camptothecin (SN38) are broad-spectrum cytotoxic anticancer agents. Both cause cell death in rapidly dividing cells (e.g., cancer cells, epithelial cells, hematopoietic cells) and commensal bacteria. Therefore, CPT11 can induce a series o...
Autores principales: | Yue, Bei, Gao, Ruiyang, Wang, Zhengtao, Dou, Wei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553258/ https://www.ncbi.nlm.nih.gov/pubmed/34722328 http://dx.doi.org/10.3389/fcimb.2021.710945 |
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