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Prenatal overexpression of platelet‐derived growth factor receptor A results in central nervous system hypomyelination
BACKGROUND: Platelet‐derived growth factor (PDGF) signaling, through the ligand PDGF‐A and its receptor PDGFRA, is important for the growth and maintenance of oligodendrocyte progenitor cells (OPCs) in the central nervous system (CNS). PDGFRA signaling is downregulated prior to OPC differentiation i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553322/ https://www.ncbi.nlm.nih.gov/pubmed/34480532 http://dx.doi.org/10.1002/brb3.2332 |