Prenatal overexpression of platelet‐derived growth factor receptor A results in central nervous system hypomyelination

BACKGROUND: Platelet‐derived growth factor (PDGF) signaling, through the ligand PDGF‐A and its receptor PDGFRA, is important for the growth and maintenance of oligodendrocyte progenitor cells (OPCs) in the central nervous system (CNS). PDGFRA signaling is downregulated prior to OPC differentiation i...

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Detalles Bibliográficos
Autores principales: Cardona, Herminio Joey, Somasundaram, Agila, Crabtree, Donna M., Gadd, Samantha L., Becher, Oren J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553322/
https://www.ncbi.nlm.nih.gov/pubmed/34480532
http://dx.doi.org/10.1002/brb3.2332

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