Fibrinogen αC-subregions critically contribute blood clot fibre growth, mechanical stability, and resistance to fibrinolysis

Fibrinogen is essential for blood coagulation. The C-terminus of the fibrinogen α-chain (αC-region) is composed of an αC-domain and αC-connector. Two recombinant fibrinogen variants (α390 and α220) were produced to investigate the role of subregions in modulating clot stability and resistance to lys...

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Detalles Bibliográficos
Autores principales: McPherson, Helen R, Duval, Cedric, Baker, Stephen R, Hindle, Matthew S, Cheah, Lih T, Asquith, Nathan L, Domingues, Marco M, Ridger, Victoria C, Connell, Simon DA, Naseem, Khalid M, Philippou, Helen, Ajjan, Ramzi A, Ariëns, Robert AS
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553339/
https://www.ncbi.nlm.nih.gov/pubmed/34633287
http://dx.doi.org/10.7554/eLife.68761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553339/
https://www.ncbi.nlm.nih.gov/pubmed/34633287
http://dx.doi.org/10.7554/eLife.68761

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