A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein

The Nsp9 replicase is a conserved coronaviral protein that acts as an essential accessory component of the multi-subunit viral replication/transcription complex. Nsp9 is the predominant substrate for the essential nucleotidylation activity of Nsp12. Compounds specifically interfering with this viral...

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Detalles Bibliográficos
Autores principales: Littler, Dene R., Liu, Miaomiao, McAuley, Julie L., Lowery, Shea A., Illing, Patricia T., Gully, Benjamin S., Purcell, Anthony W., Chandrashekaran, Indu R., Perlman, Stanley, Purcell, Damian F.J., Quinn, Ronald J., Rossjohn, Jamie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553373/
https://www.ncbi.nlm.nih.gov/pubmed/34756886
http://dx.doi.org/10.1016/j.jbc.2021.101362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553373/
https://www.ncbi.nlm.nih.gov/pubmed/34756886
http://dx.doi.org/10.1016/j.jbc.2021.101362

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