Cargando…

A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein

The Nsp9 replicase is a conserved coronaviral protein that acts as an essential accessory component of the multi-subunit viral replication/transcription complex. Nsp9 is the predominant substrate for the essential nucleotidylation activity of Nsp12. Compounds specifically interfering with this viral...

Descripción completa

Detalles Bibliográficos
Autores principales:	Littler, Dene R., Liu, Miaomiao, McAuley, Julie L., Lowery, Shea A., Illing, Patricia T., Gully, Benjamin S., Purcell, Anthony W., Chandrashekaran, Indu R., Perlman, Stanley, Purcell, Damian F.J., Quinn, Ronald J., Rossjohn, Jamie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553373/ https://www.ncbi.nlm.nih.gov/pubmed/34756886 http://dx.doi.org/10.1016/j.jbc.2021.101362

Ejemplares similares

Inside-out: Antibody-binding reveals potential folding hinge-points within the SARS-CoV-2 replication co-factor nsp9
por: Pan, Yue, et al.
Publicado: (2023)

Binding Studies of the Prodrug HAO472 to SARS-Cov-2 Nsp9 and Variants
por: Liu, Miaomiao, et al.
Publicado: (2022)

Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9
por: Littler, Dene R., et al.
Publicado: (2020)

Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9
por: Littler, Dene R., et al.
Publicado: (2021)

Collision-Induced Affinity Selection Mass Spectrometry for Identification of Ligands
por: Mak, Tin, et al.
Publicado: (2022)

Complimentary electrostatics dominate T-cell receptor binding to a psoriasis-associated peptide antigen presented by human leukocyte antigen C∗06:02
por: Anand, Sushma, et al.
Publicado: (2023)

Crystal structures of pertussis toxin with NAD(+) and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity
por: Sakari, Moona, et al.
Publicado: (2022)

Rotaviral and Coronaviral Diarrhea
por: Torres-Medina, Alfonso, et al.
Publicado: (1985)

Targeting Coronaviral Replication and Cellular JAK2 Mediated Dominant NF-κB Activation for Comprehensive and Ultimate Inhibition of Coronaviral Activity
por: Yang, Cheng-Wei, et al.
Publicado: (2017)

In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins
por: Athmer, Jeremiah, et al.
Publicado: (2017)

Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication
por: Oudshoorn, Diede, et al.
Publicado: (2017)

A pocket guide on how to structure SARS-CoV-2 drugs and therapies
por: Littler, Dene R., et al.
Publicado: (2020)

The Efficacy of Common Household Cleaning Agents for SARS-CoV-2 Infection Control
por: Almeida, Catarina F., et al.
Publicado: (2022)

Ferret Systemic Coronaviral Disease (FSCD)
Publicado: (2013)

SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon
por: Shemesh, Maya, et al.
Publicado: (2021)

Prevention of Cytotoxic T Cell Escape Using a Heteroclitic Subdominant Viral T Cell Determinant
por: Butler, Noah S., et al.
Publicado: (2008)

Correction: SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon
por: Shemesh, Maya, et al.
Publicado: (2021)

Evaluation of virucidal activity of residual quaternary ammonium-treated surfaces on SARS-CoV-2
por: Caschera, Alexander G., et al.
Publicado: (2022)

Feline Infectious Peritonitis: An Immune-Mediated Coronaviral Vasculitis
por: August, John R.
Publicado: (1984)

Our evolving understanding of the role of the γδ T cell receptor in γδ T cell mediated immunity
por: Gully, Benjamin S., et al.
Publicado: (2021)

Re: Controversy in coronaViral Imaging and Diagnostics (COVID)
por: Morozov, S., et al.
Publicado: (2020)

Host proteases as determinants of coronaviral neurotropism and virulence
por: Vavougios, George D.
Publicado: (2020)

Lithium and coronaviral infections. A scoping review.
por: Nowak, Jan K., et al.
Publicado: (2020)

Controversy in coronaViral Imaging and Diagnostics (COVID)
por: Hamilton, M.C.K., et al.
Publicado: (2020)

Neuroimmune multi-hit perspective of coronaviral infection
por: Hayley, Shawn, et al.
Publicado: (2021)

Coronaviral RNA-methyltransferases: function, structure and inhibition
por: Nencka, Radim, et al.
Publicado: (2022)

Impacts of p97 on Proteome Changes in Human Cells during Coronaviral Replication
por: Cheng, Kai-Wen, et al.
Publicado: (2021)

Protocol for production and expression of chimeric bovine-human monoclonal antibodies
por: Heydarchi, Behnaz, et al.
Publicado: (2022)

Carbamazepine Induces Focused T Cell Responses in Resolved Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Cases But Does Not Perturb the Immunopeptidome for T Cell Recognition
por: Mifsud, Nicole A., et al.
Publicado: (2021)

COVID-19 and coronaviral hepatitis: evidence of collateral damage
por: Parvez, Mohammad K
Publicado: (2020)

Therapeutic Potential of Glycosyl Flavonoids as Anti-Coronaviral Agents
por: Godinho, Patrícia I. C., et al.
Publicado: (2021)

Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19
por: Lowery, Shea A., et al.
Publicado: (2021)

Optimal preparation of SARS-CoV-2 viral transport medium for culture
por: McAuley, Julie, et al.
Publicado: (2021)

Liquid Chalk Is an Antiseptic against SARS-CoV-2 and Influenza A Respiratory Viruses
por: McAuley, Julie L., et al.
Publicado: (2021)

Andrographolide binds to spike glycoprotein and RNA-dependent RNA polymerase (NSP12) of SARS-CoV-2 by in silico approach: a probable molecule in the development of anti-coronaviral drug
por: Srikanth, Lokanathan, et al.
Publicado: (2021)

Effects of Mutagenesis of Murine Hepatitis Virus NSP1 and NSP14 on Replication in Culture
por: Eckerle, Lance D., et al.
Publicado: (2006)

Regulation of Coronaviral Poly(A) Tail Length during Infection
por: Wu, Hung-Yi, et al.
Publicado: (2013)

Membrane and Phospholipid Binding by Murine Coronaviral Nucleocapsid N Protein
por: Anderson, Robert, et al.
Publicado: (1993)

Modulation of lysosomal function as a therapeutic approach for coronaviral infections
por: Liu, Yuan, et al.
Publicado: (2021)

Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication
por: Wilamowski, Mateusz, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4ouritt4t9cvsr1hufbem5pt8e