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Okamoto model for necrosis and its expansions, CD38-cyclic ADP-ribose signal system for intracellular Ca(2+) mobilization and Reg (Regenerating gene protein)-Reg receptor system for cell regeneration
In pancreatic islet cell culture models and animal models, we studied the molecular mechanisms involved in the development of insulin-dependent diabetes. The diabetogenic agents, alloxan and streptozotocin, caused DNA strand breaks, which in turn activated poly(ADP-ribose) polymerase/synthetase (PAR...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Japan Academy
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553518/ https://www.ncbi.nlm.nih.gov/pubmed/34629354 http://dx.doi.org/10.2183/pjab.97.022 |