Structural basis for human ZBTB7A action at the fetal globin promoter

Elevated levels of fetal globin protect against β-hemoglobinopathies, such as sickle cell disease and β-thalassemia. Two zinc-finger (ZF) repressors, BCL11A and ZBTB7A/LRF, bind directly to the fetal globin promoter elements positioned at −115 and −200, respectively. Here, we describe X-ray structur...

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Detalles Bibliográficos
Autores principales: Yang, Yang, Ren, Ren, Ly, Lana C., Horton, John R., Li, Fudong, Quinlan, Kate G.R., Crossley, Merlin, Shi, Yunyu, Cheng, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553545/
https://www.ncbi.nlm.nih.gov/pubmed/34592153
http://dx.doi.org/10.1016/j.celrep.2021.109759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553545/
https://www.ncbi.nlm.nih.gov/pubmed/34592153
http://dx.doi.org/10.1016/j.celrep.2021.109759

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