Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology

Amyotrophic lateral sclerosis overlapping with frontotemporal dementia (ALS/FTD) is a fatal and currently untreatable disease characterized by rapid cognitive decline and paralysis. Elucidating initial cellular pathologies is central to therapeutic target development, but obtaining samples from pres...

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Detalles Bibliográficos
Autores principales: Szebényi, Kornélia, Wenger, Léa M. D., Sun, Yu, Dunn, Alexander W. E., Limegrover, Colleen A., Gibbons, George M., Conci, Elena, Paulsen, Ole, Mierau, Susanna B., Balmus, Gabriel, Lakatos, András
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553627/
https://www.ncbi.nlm.nih.gov/pubmed/34675437
http://dx.doi.org/10.1038/s41593-021-00923-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553627/
https://www.ncbi.nlm.nih.gov/pubmed/34675437
http://dx.doi.org/10.1038/s41593-021-00923-4

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