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Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology

Amyotrophic lateral sclerosis overlapping with frontotemporal dementia (ALS/FTD) is a fatal and currently untreatable disease characterized by rapid cognitive decline and paralysis. Elucidating initial cellular pathologies is central to therapeutic target development, but obtaining samples from pres...

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Detalles Bibliográficos
Autores principales:	Szebényi, Kornélia, Wenger, Léa M. D., Sun, Yu, Dunn, Alexander W. E., Limegrover, Colleen A., Gibbons, George M., Conci, Elena, Paulsen, Ole, Mierau, Susanna B., Balmus, Gabriel, Lakatos, András
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553627/ https://www.ncbi.nlm.nih.gov/pubmed/34675437 http://dx.doi.org/10.1038/s41593-021-00923-4

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