Ion-pair interactions between voltage-sensing domain IV and pore domain I regulate Ca(V)1.1 gating

The voltage-gated calcium channel Ca(V)1.1 belongs to the family of pseudo-heterotetrameric cation channels, which are built of four structurally and functionally distinct voltage-sensing domains (VSDs) arranged around a common channel pore. Upon depolarization, positive gating charges in the S4 hel...

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Detalles Bibliográficos
Autores principales: El Ghaleb, Yousra, Fernández-Quintero, Monica L., Monteleone, Stefania, Tuluc, Petronel, Campiglio, Marta, Liedl, Klaus R., Flucher, Bernhard E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553663/
https://www.ncbi.nlm.nih.gov/pubmed/34506774
http://dx.doi.org/10.1016/j.bpj.2021.09.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553663/
https://www.ncbi.nlm.nih.gov/pubmed/34506774
http://dx.doi.org/10.1016/j.bpj.2021.09.004

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