Cargando…

Ion-pair interactions between voltage-sensing domain IV and pore domain I regulate Ca(V)1.1 gating

The voltage-gated calcium channel Ca(V)1.1 belongs to the family of pseudo-heterotetrameric cation channels, which are built of four structurally and functionally distinct voltage-sensing domains (VSDs) arranged around a common channel pore. Upon depolarization, positive gating charges in the S4 hel...

Descripción completa

Detalles Bibliográficos
Autores principales:	El Ghaleb, Yousra, Fernández-Quintero, Monica L., Monteleone, Stefania, Tuluc, Petronel, Campiglio, Marta, Liedl, Klaus R., Flucher, Bernhard E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Biophysical Society 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553663/ https://www.ncbi.nlm.nih.gov/pubmed/34506774 http://dx.doi.org/10.1016/j.bpj.2021.09.004

Ejemplares similares

Structural determinants of voltage-gating properties in calcium channels
por: Fernández-Quintero, Monica L, et al.
Publicado: (2021)

Mechanisms Responsible for ω-Pore Currents in Ca(v) Calcium Channel Voltage-Sensing Domains
por: Monteleone, Stefania, et al.
Publicado: (2017)

Role of putative voltage-sensor countercharge D4 in regulating gating properties of Ca(V)1.2 and Ca(V)1.3 calcium channels
por: Costé de Bagneaux, Pierre, et al.
Publicado: (2018)

Calcium current modulation by the γ(1) subunit depends on alternative splicing of Ca(V)1.1
por: El Ghaleb, Yousra, et al.
Publicado: (2022)

Correcting the R165K substitution in the first voltage-sensor of Ca(V)1.1 right-shifts the voltage-dependence of skeletal muscle calcium channel activation
por: El Ghaleb, Yousra, et al.
Publicado: (2019)

Two distinct voltage-sensing domains control voltage sensitivity and kinetics of current activation in Ca(V)1.1 calcium channels
por: Tuluc, Petronel, et al.
Publicado: (2016)

STAC proteins associate to the IQ domain of Ca(V)1.2 and inhibit calcium-dependent inactivation
por: Campiglio, Marta, et al.
Publicado: (2018)

How and why are calcium currents curtailed in the skeletal muscle voltage‐gated calcium channels?
por: Flucher, Bernhard E., et al.
Publicado: (2017)

STAC3 stably interacts through its C1 domain with Ca(V)1.1 in skeletal muscle triads
por: Campiglio, Marta, et al.
Publicado: (2017)

CACNA1I gain-of-function mutations differentially affect channel gating and cause neurodevelopmental disorders
por: El Ghaleb, Yousra, et al.
Publicado: (2021)

The Role of Auxiliary Subunits for the Functional Diversity of Voltage-Gated Calcium Channels
por: Campiglio, Marta, et al.
Publicado: (2015)

Stapled Voltage-Gated Calcium Channel (Ca(V)) α-Interaction Domain (AID) Peptides Act As Selective Protein–Protein Interaction Inhibitors of Ca(V) Function
por: Findeisen, Felix, et al.
Publicado: (2017)

Specific contributions of the four voltage-sensing domains in L-type calcium channels to gating and modulation
por: Flucher, Bernhard E.
Publicado: (2016)

Physiological and Pharmacological Modulation of the Embryonic Skeletal Muscle Calcium Channel Splice Variant Ca(V)1.1e
por: Benedetti, Bruno, et al.
Publicado: (2015)

Correction: Specific contributions of the four voltage-sensing domains in L-type calcium channels to gating and modulation
por: Flucher, Bernhard E.
Publicado: (2016)

Role of High Voltage-Gated Ca(2+) Channel Subunits in Pancreatic β-Cell Insulin Release. From Structure to Function
por: Tuluc, Petronel, et al.
Publicado: (2021)

The voltage-sensing domain of a phosphatase gates the pore of a potassium channel
por: Arrigoni, Cristina, et al.
Publicado: (2013)

Structural insights into binding of STAC proteins to voltage-gated calcium channels
por: Wong King Yuen, Siobhan M., et al.
Publicado: (2017)

Gating defects of disease-causing de novo mutations in Ca(v)1.3 Ca(2+) channels
por: Pinggera, Alexandra, et al.
Publicado: (2018)

Atomic Constraints between the Voltage Sensor and the Pore Domain in a Voltage-gated K(+) Channel of Known Structure
por: Lewis, Anthony, et al.
Publicado: (2008)

Gating pore currents occur in Ca(V)1.1 domain III mutants associated with HypoPP
por: Wu, Fenfen, et al.
Publicado: (2021)

Asymmetric Contribution of a Selectivity Filter Gate in Triggering Inactivation of Ca(V)1.3 Channels
por: del Rivero Morfin, Pedro J., et al.
Publicado: (2023)

Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains
por: Lörinczi, Éva, et al.
Publicado: (2015)

Conformational rearrangements in the second voltage sensor domain switch PIP(2)- and voltage-gating modes in two-pore channels
por: Shimomura, Takushi, et al.
Publicado: (2023)

Biophysical classification of a CACNA1D de novo mutation as a high-risk mutation for a severe neurodevelopmental disorder
por: Hofer, Nadja T., et al.
Publicado: (2020)

Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca(2+) channel activators
por: Ortner, Nadine J., et al.
Publicado: (2014)

CACNA1D De Novo Mutations in Autism Spectrum Disorders Activate Cav1.3 L-Type Calcium Channels
por: Pinggera, Alexandra, et al.
Publicado: (2015)

Functional Architecture of the Inner Pore of a Voltage-gated Ca(2+) Channel
por: Zhen, Xiao-guang, et al.
Publicado: (2005)

Domain assembly of NAADP-gated two-pore channels
por: Churamani, Dev, et al.
Publicado: (2011)

A homology model of the pore domain of a voltage-gated calcium channel is consistent with available SCAM data
por: Bruhova, Iva, et al.
Publicado: (2010)

Two-pore domain potassium channels enable action potential generation in the absence of voltage-gated potassium channels
por: MacKenzie, Georgina, et al.
Publicado: (2014)

Gating mechanism of Kv11.1 (hERG) K(+) channels without covalent connection between voltage sensor and pore domains
por: de la Peña, Pilar, et al.
Publicado: (2017)

Distinct roles for Ca(V)1.1’s voltage-sensing domains
por: Short, Ben
Publicado: (2021)

Stabilization of negative activation voltages of Cav1.3 L-Type Ca(2+)-channels by alternative splicing
por: Hofer, Nadja T., et al.
Publicado: (2020)

A conformational change of the domain IV S6 segment of the voltage-gated sodium channel during inactivation
por: Gawali, Vaibhavkumar S, et al.
Publicado: (2012)

Chemical shift assignments of the C-terminal domain of CaBP1 bound to the IQ-motif of voltage-gated Ca(2+) channel (Ca(V)1.2)
por: Salveson, Ian, et al.
Publicado: (2022)

C-Terminal Modulatory Domain Controls Coupling of Voltage-Sensing to Pore Opening in Ca(v)1.3 L-type Ca(2+) Channels
por: Lieb, Andreas, et al.
Publicado: (2014)

Cytoplasmic Domains and Voltage-Dependent Potassium Channel Gating
por: Barros, Francisco, et al.
Publicado: (2012)

Mutations in the Voltage Sensors of Domains I and II of Na(v)1.5 that are Associated with Arrhythmias and Dilated Cardiomyopathy Generate Gating Pore Currents
por: Moreau, Adrien, et al.
Publicado: (2015)

Caution Is Required in Interpretation of Mutations in the Voltage Sensing Domain of Voltage Gated Channels as Evidence for Gating Mechanisms
por: Kariev, Alisher M., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_eurvqmosm0tjsc57n72usia7ll