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Pharmacogenomics characterization of the MDM2 inhibitor MI-773 reveals candidate tumours and predictive biomarkers

MI-773 is a recently developed small-molecule inhibitor of the mouse double minute 2 (MDM2) proto-oncogene. Preclinical data on the anti-tumour activity of MI-773 are limited and indicate that tumour cell lines (CLs) with mutated TP53 are more resistant to MI-773 than wild type TP53. Here, we explor...

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Detalles Bibliográficos
Autores principales: Vuaroqueaux, Vincent, Hendriks, Hans R., Al-Hasani, Hoor, Peille, Anne-Lise, Das, Samayita, Fiebig, Heinz-Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553758/
https://www.ncbi.nlm.nih.gov/pubmed/34711913
http://dx.doi.org/10.1038/s41698-021-00235-7