Cargando…

Loss of hepatic Flcn protects against fibrosis and inflammation by activating autophagy pathways

Non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease worldwide and can progress to non-alcoholic steatohepatitis (NASH), which is characterized by triglyceride accumulation, inflammation, and fibrosis. No pharmacological agents are currently approved to treat these conditions...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paquette, Mathieu, Yan, Ming, Ramírez-Reyes, Josué M. J., El-Houjeiri, Leeanna, Biondini, Marco, Dufour, Catherine R., Jeong, Hyeonju, Pacis, Alain, Giguère, Vincent, Estall, Jennifer L., Siegel, Peter M., Audet-Walsh, Étienne, Pause, Arnim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553785/ https://www.ncbi.nlm.nih.gov/pubmed/34711912 http://dx.doi.org/10.1038/s41598-021-99958-7

Ejemplares similares

mTOR Pathways in Cancer and Autophagy
por: Paquette, Mathieu, et al.
Publicado: (2018)

Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα
por: Yan, Ming, et al.
Publicado: (2016)

FLCN: A new regulator of AMPK-dependent Warburg metabolic reprogramming
por: Gingras, Marie-Claude, et al.
Publicado: (2014)

FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores
por: Possik, Elite, et al.
Publicado: (2015)

Folliculin: A Regulator of Transcription Through AMPK and mTOR Signaling Pathways
por: Ramirez Reyes, Josué M. J., et al.
Publicado: (2021)

Inhibition of DNMT1 and ERRα crosstalk suppresses breast cancer via derepression of IRF4
por: Vernier, Mathieu, et al.
Publicado: (2020)

Blood and lymphatic systems are segregated by the FLCN tumor suppressor
por: Tai-Nagara, Ikue, et al.
Publicado: (2020)

Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-β signaling
por: Hong, Seung-Beom, et al.
Publicado: (2010)

FLCN regulates transferrin receptor 1 transport and iron homeostasis
por: Wang, Xiaojuan, et al.
Publicado: (2021)

Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression
por: Wu, Mingsong, et al.
Publicado: (2015)

FLCN Maintains the Leucine Level in Lysosome to Stimulate mTORC1
por: Wu, Xiaochun, et al.
Publicado: (2016)

Estrogen-related receptors are targetable ROS sensors
por: Vernier, Mathieu, et al.
Publicado: (2020)

Deficiency of FLCN in Mouse Kidney Led to Development of Polycystic Kidneys and Renal Neoplasia
por: Chen, Jindong, et al.
Publicado: (2008)

Birt-Hogg-Dubé syndrome in two Chinese families with mutations in the FLCN gene
por: Hou, Xiaocan, et al.
Publicado: (2018)

A novel FLCN mutation in family members diagnosed with primary spontaneous pneumothorax
por: Genc Yavuz, Burcu, et al.
Publicado: (2019)

Genotypic characteristics of Chinese patients with BHD syndrome and functional analysis of FLCN variants
por: Liu, Keqiang, et al.
Publicado: (2019)

Role of FLCN Phosphorylation in Insulin‐Mediated mTORC1 Activation and Tumorigenesis
por: Wang, Guoyan, et al.
Publicado: (2023)

Correction: Deficiency of FLCN in Mouse Kidney Led to Development of Polycystic Kidneys and Renal Neoplasia
por: Chen, Jindong, et al.
Publicado: (2008)

Correction: Deficiency of FLCN in Mouse Kidney Led to Development of Polycystic Kidneys and Renal Neoplasia
por: Chen, Jindong, et al.
Publicado: (2008)

Are lung cysts in renal cell cancer (RCC) patients an indication for FLCN mutation analysis?
por: Johannesma, Paul C., et al.
Publicado: (2015)

Phosphoproteomic Analysis of FLCN Inactivation Highlights Differential Kinase Pathways and Regulatory TFEB Phosphoserines
por: Glykofridis, Iris E., et al.
Publicado: (2022)

A Novel FLCN Variant in a Suspected Birt–Hogg–Dubè Syndrome Patient
por: Bandini, Erika, et al.
Publicado: (2023)

Editorial: AMPK and mTOR Beyond Signaling: Emerging Roles in Transcriptional Regulation
por: Audet-Walsh, Étienne, et al.
Publicado: (2021)

The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue
por: Wada, Shogo, et al.
Publicado: (2016)

Characterization of a splice-site mutation in the tumor suppressor gene FLCN associated with renal cancer
por: Bartram, Malte P., et al.
Publicado: (2017)

AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR
por: Collodet, Caterina, et al.
Publicado: (2019)

Genetic insight into Birt–Hogg–Dubé syndrome in Indian patients reveals novel mutations at FLCN
por: Ray, Anindita, et al.
Publicado: (2022)

A Novel FLCN Intragenic Deletion Identified by NGS in a BHDS Family and Literature Review
por: Cai, Minghui, et al.
Publicado: (2021)

Concurrent Germline and Somatic Mutations in FLCN and Preliminary Exploration of Its Function: A Case Report
por: Wang, Tao, et al.
Publicado: (2022)

SAT179 Germline And Somatic Inactivating FLCN Variants In Parathyroid Cancer and Atypical Parathyroid Tumors
por: Jha, Smita, et al.
Publicado: (2023)

Birt–Hogg–Dubé syndrome: novel FLCN frameshift deletion in daughter and father with renal cell carcinomas
por: Näf, Ernst, et al.
Publicado: (2015)

Novel germline mutations in FLCN gene identified in two Chinese patients with Birt–Hogg–Dubé syndrome
por: Li, Teng, et al.
Publicado: (2017)

FLCN Regulates HIF2α Nuclear Import and Proliferation of Clear Cell Renal Cell Carcinoma
por: Zhao, Xuyang, et al.
Publicado: (2020)

A novel FLCN gene mutation causing Birt–Hogg–Dubé syndrome in a Korean family
por: Bae, Jiyeon, et al.
Publicado: (2022)

Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes
por: Kazan, Jalal M., et al.
Publicado: (2021)

Folliculin Regulates Ampk-Dependent Autophagy and Metabolic Stress Survival
por: Possik, Elite, et al.
Publicado: (2014)

Inactivation of the FLCN Tumor Suppressor Gene Induces TFE3 Transcriptional Activity by Increasing Its Nuclear Localization
por: Hong, Seung-Beom, et al.
Publicado: (2010)

A Case of Birt-Hogg-Dubé (BHD) Syndrome Harboring a Novel Folliculin (FLCN) Gene Mutation
por: Yukawa, Takuro, et al.
Publicado: (2016)

FLCN-regulated miRNAs suppressed reparative response in cells and pulmonary lesions of Birt-Hogg-Dubé syndrome
por: Min, Haiyan, et al.
Publicado: (2020)

A systematic review assessing the existence of pneumothorax-only variants of FLCN. Implications for lifelong surveillance of renal tumours
por: Matsumoto, Kenki, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4m8ehbg8ksc93v6mtlpmcqvkv4