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Sperm epigenetic alterations contribute to inter- and transgenerational effects of paternal exposure to long-term psychological stress via evading offspring embryonic reprogramming

Paternal life experiences impact offspring health via germline, and epigenetic inheritance provides a potential mechanism. However, global reprogramming during offspring embryogenesis and gametogenesis represents the largest hurdle to conceptualize it. Yet, detailed characterization of how sperm epi...

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Detalles Bibliográficos
Autores principales: Zheng, Xiaoguo, Li, Zhenhua, Wang, Guishuan, Wang, Hanshu, Zhou, Yuchuan, Zhao, Xinzhi, Cheng, C. Yan, Qiao, Yunbo, Sun, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553786/
https://www.ncbi.nlm.nih.gov/pubmed/34711814
http://dx.doi.org/10.1038/s41421-021-00343-5