Schisandrin B Antagonizes Cardiotoxicity Induced by Pirarubicin by Inhibiting Mitochondrial Permeability Transition Pore (mPTP) Opening and Decreasing Cardiomyocyte Apoptosis

Objective: Pirarubicin (THP), one of the anthracycline anticancer drugs, is widely used in the treatment of various cancers, but its cardiotoxicity cannot be ignored. Schisandrin B (SchB) has the ability to upregulate cellular antioxidant defense mechanism and promote mitochondrial function and anti...

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Detalles Bibliográficos
Autores principales: Shi, Hongwei, Tang, Heng, Ai, Wen, Zeng, Qingfu, Yang, Hong, Zhu, Fengqing, Wei, Yunjie, Feng, Rui, Wen, Li, Pu, Peng, He, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554014/
https://www.ncbi.nlm.nih.gov/pubmed/34721023
http://dx.doi.org/10.3389/fphar.2021.733805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554014/
https://www.ncbi.nlm.nih.gov/pubmed/34721023
http://dx.doi.org/10.3389/fphar.2021.733805

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