Cargando…

Snake venom phospholipase A(2)s exhibit strong virucidal activity against SARS-CoV-2 and inhibit the viral spike glycoprotein interaction with ACE2

The COVID-19 pandemic caused by SARS-CoV-2 requires new treatments both to alleviate the symptoms and to prevent the spread of this disease. Previous studies demonstrated good antiviral and virucidal activity of phospholipase A(2)s (PLA(2)s) from snake venoms against viruses from different families...

Descripción completa

Detalles Bibliográficos
Autores principales:	Siniavin, Andrei E., Streltsova, Maria A., Nikiforova, Maria A., Kudryavtsev, Denis S., Grinkina, Svetlana D., Gushchin, Vladimir A., Mozhaeva, Vera A., Starkov, Vladislav G., Osipov, Alexey V., Lummis, Sarah C. R., Tsetlin, Victor I., Utkin, Yuri N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554752/ https://www.ncbi.nlm.nih.gov/pubmed/34714362 http://dx.doi.org/10.1007/s00018-021-03985-6

Ejemplares similares

Anti-HIV Activity of Snake Venom Phospholipase A2s: Updates for New Enzymes and Different Virus Strains
por: Siniavin, Andrei, et al.
Publicado: (2022)

Inhibition of Nicotinic Acetylcholine Receptors, a Novel Facet in the Pleiotropic Activities of Snake Venom Phospholipases A(2)
por: Vulfius, Catherine A., et al.
Publicado: (2014)

Pancreatic and snake venom presynaptically active phospholipases A(2) inhibit nicotinic acetylcholine receptors
por: Vulfius, Catherine A., et al.
Publicado: (2017)

Quantitative Proteomic Analysis of Venoms from Russian Vipers of Pelias Group: Phospholipases A(2) are the Main Venom Components
por: Kovalchuk, Sergey I., et al.
Publicado: (2016)

What Are the Neurotoxins in Hemotoxic Snake Venoms?
por: Osipov, Alexey, et al.
Publicado: (2023)

Activation of α7 Nicotinic Acetylcholine Receptor Upregulates HLA-DR and Macrophage Receptors: Potential Role in Adaptive Immunity and in Preventing Immunosuppression
por: Siniavin, Andrei E., et al.
Publicado: (2020)

Analysis of nociceptive effects of neurotoxic phospholipase A2 from Vipera nikolskii venom in mice
por: Dyachenko, Igor A, et al.
Publicado: (2013)

Screening Snake Venoms for Toxicity to Tetrahymena Pyriformis Revealed Anti-Protozoan Activity of Cobra Cytotoxins
por: Kuleshina, Olga N., et al.
Publicado: (2020)

Phospholipase A(2) from krait Bungarus fasciatus venom induces human cancer cell death in vitro
por: Tran, Thien V., et al.
Publicado: (2019)

Does Cholinergic Stimulation Affect the P2X7 Receptor-Mediated Dye Uptake in Mast Cells and Macrophages?
por: Nurkhametova, Dilyara, et al.
Publicado: (2020)

Insights into the antiviral activity of phospholipases A(2) (PLA(2)s) from snake venoms
por: Teixeira, S.C., et al.
Publicado: (2020)

Antitumoral Potential of Tunisian Snake Venoms Secreted Phospholipases A(2)
por: Zouari-Kessentini, Raoudha, et al.
Publicado: (2013)

Rapid Identification of Phospholipase A(2) Transcripts from Snake Venoms
por: Jia, Ying, et al.
Publicado: (2019)

Contextual Constraints: Dynamic Evolution of Snake Venom Phospholipase A(2)
por: Suranse, Vivek, et al.
Publicado: (2022)

Therapeutic application of natural inhibitors against snake venom phospholipase A(2)
por: Perumal Samy, Ramar, et al.
Publicado: (2012)

Short Linear Motifs Characterizing Snake Venom and Mammalian Phospholipases A2
por: Peggion, Caterina, et al.
Publicado: (2021)

In Vitro Antiplasmodial Activity of Phospholipases A(2) and a Phospholipase Homologue Isolated from the Venom of the Snake Bothrops asper
por: Castillo, Juan Carlos Quintana, et al.
Publicado: (2012)

Cytotoxic and inflammatory potential of a phospholipase A(2) from Bothrops jararaca snake venom
por: Cedro, Rafhaella C. A., et al.
Publicado: (2018)

Inventing an arsenal: adaptive evolution and neofunctionalization of snake venom phospholipase A(2 )genes
por: Lynch, Vincent J
Publicado: (2007)

SDS-induced oligomerization of Lys49-phospholipase A(2) from snake venom
por: Matsui, Takashi, et al.
Publicado: (2019)

Diversity of Phospholipases A(2) from Bothrops atrox Snake Venom: Adaptive Advantages for Snakes Compromising Treatments for Snakebite Patients
por: Sousa, Leijiane F., et al.
Publicado: (2022)

Snake C-type lectin-like proteins inhibit nicotinic acetylcholine receptors
por: Kryukova, Elena V, et al.
Publicado: (2020)

S- and P-type cobra venom cardiotoxins differ in their action on isolated rat heart
por: Averin, Alexey S., et al.
Publicado: (2022)

Antiviral Effects of Animal Toxins: Is There a Way to Drugs?
por: Utkin, Yuri, et al.
Publicado: (2022)

Effects of Cardiotoxins from Naja oxiana Cobra Venom on Rat Heart Muscle and Aorta: A Comparative Study of Toxin-Induced Contraction Mechanisms
por: Averin, Alexey S., et al.
Publicado: (2022)

Varespladib Inhibits the Phospholipase A(2) and Coagulopathic Activities of Venom Components from Hemotoxic Snakes
por: Xie, Chunfang, et al.
Publicado: (2020)

Inflammasome Activation Induced by a Snake Venom Lys49-Phospholipase A(2) Homologue
por: Boeno, Charles Nunes, et al.
Publicado: (2019)

Cytotoxicity of snake venom enzymatic toxins: phospholipase A(2) and l-amino acid oxidase
por: Hiu, Jia Jin, et al.
Publicado: (2020)

Snake Venom-specific Phospholipase A2: A Diagnostic Marker for the Management of Snakebite Cases
por: Kaulgud, Ram S, et al.
Publicado: (2022)

Snake Venom Cytotoxins, Phospholipase A(2)s, and Zn(2+)-dependent Metalloproteinases: Mechanisms of Action and Pharmacological Relevance
por: Gasanov, Sardar E, et al.
Publicado: (2014)

Snake Toxins Labeled by Green Fluorescent Protein or Its Synthetic Chromophore are New Probes for Nicotinic acetylcholine Receptors
por: Kasheverov, Igor E., et al.
Publicado: (2021)

The Sequence and Three-Dimensional Structure Characterization of Snake Venom Phospholipases B
por: Ullah, Anwar, et al.
Publicado: (2020)

Secreted Phospholipases A(2) of Snake Venoms: Effects on the Peripheral Neuromuscular System with Comments on the Role of Phospholipases A(2) in Disorders of the CNS and Their Uses in Industry
por: Harris, John B., et al.
Publicado: (2013)

Cobra Venom Factor and Ketoprofen Abolish the Antitumor Effect of Nerve Growth Factor from Cobra Venom
por: Osipov, Alexey V., et al.
Publicado: (2017)

New multienzymatic complex formed between human cathepsin D and snake venom phospholipase A(2)
por: Moraes, Jeane do Nascimento, et al.
Publicado: (2022)

Novel Bradykinin-Potentiating Peptides and Three-Finger Toxins from Viper Venom: Combined NGS Venom Gland Transcriptomics and Quantitative Venom Proteomics of the Azemiops feae Viper
por: Babenko, Vladislav V., et al.
Publicado: (2020)

The Potassium Channel Blocker β-Bungarotoxin from the Krait Bungarus multicinctus Venom Manifests Antiprotozoal Activity
por: Osipov, Alexey V., et al.
Publicado: (2023)

Comparative characterization of Viperidae snake venoms from Perú reveals two compositional patterns of phospholipase A(2) expression
por: Lomonte, Bruno, et al.
Publicado: (2020)

Antibiofilm Activity of Acidic Phospholipase Isoform Isolated from Bothrops erythromelas Snake Venom
por: Nunes, Ellynes, et al.
Publicado: (2020)

Synergism between Basic Asp49 and Lys49 Phospholipase A(2) Myotoxins of Viperid Snake Venom In Vitro and In Vivo
por: Mora-Obando, Diana, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_eda1dlijltqdgh5udcfttg2t95