CXCR5 down-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy: potential role of microglial autophagy and the p38MAPK/NF-κB/STAT3 signaling pathway

BACKGROUND: Cognitive deficits are common in patients with sepsis. Previous studies in sepsis-associated encephalopathy (SAE) implicated the C-X-C chemokine receptor type (CXCR) 5. The present study used a mouse model of SAE to examine whether CXCR5 down-regulation could attenuate cognitive deficits...

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Detalles Bibliográficos
Autores principales: Shen, Yanan, Zhang, Yuan, Du, Jiayue, Jiang, Baochun, Shan, Tao, Li, Haojia, Bao, Hongguang, Si, Yanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554863/
https://www.ncbi.nlm.nih.gov/pubmed/34711216
http://dx.doi.org/10.1186/s12974-021-02300-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554863/
https://www.ncbi.nlm.nih.gov/pubmed/34711216
http://dx.doi.org/10.1186/s12974-021-02300-1

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