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PRCC reduces the sensitivity of cancer cells to DNA damage by inhibiting JNK and ATM/ATR pathways and results in a poor prognosis in hepatocellular carcinoma

BACKGROUND AND AIM: The proline rich mitotic checkpoint control factor (PRCC) is involved in the splicing process of pre-mRNA. This study aims to elucidate PRCC molecular function, regulatory mechanism and diagnostic value in hepatocellular carcinoma (HCC). METHODS: The tissue microarray and serum s...

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Detalles Bibliográficos
Autores principales: Liu, Chunying, Lin, Xuejing, Sun, Bin, Mao, Ziming, Chen, Lei, Qian, Haihua, Su, Changqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555229/
https://www.ncbi.nlm.nih.gov/pubmed/34715922
http://dx.doi.org/10.1186/s13578-021-00699-x