Design, computational studies, synthesis and in vitro antimicrobial evaluation of benzimidazole based thio-oxadiazole and thio-thiadiazole analogues

BACKGROUND: Two series of benzimidazole based thio-oxadiazole and thio-thiadiazole analogues were designed and synthesised as novel antimicrobial drugs through inhibition of phenylalanyl-tRNA synthetase (PheRS), which is a promising antimicrobial target. Compounds were designed to mimic the structur...

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Detalles Bibliográficos
Autores principales: Noureldin, Nada A., Richards, Jennifer, Kothayer, Hend, Baraka, Mohammed M., Eladl, Sobhy M., Wootton, Mandy, Simons, Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555319/
https://www.ncbi.nlm.nih.gov/pubmed/34711258
http://dx.doi.org/10.1186/s13065-021-00785-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555319/
https://www.ncbi.nlm.nih.gov/pubmed/34711258
http://dx.doi.org/10.1186/s13065-021-00785-8

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