Nitrous oxide as an adjunctive therapy in major depressive disorder: a randomized controlled double-blind pilot trial

OBJECTIVE: Major depressive disorder (MDD) is related to glutamatergic dysfunction. Antagonists of glutamatergic N-methyl-D-aspartate receptor (NMDAR), such as ketamine, have antidepressant properties. Nitrous oxide (N(2)O) is also a NMDAR antagonist. Thus, this study aimed to evaluate the effects o...

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Detalles Bibliográficos
Autores principales: Guimarães, Mara C., Guimarães, Tiago M., Hallak, Jaime E., Abrão, João, Machado-de-Sousa, João P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Psiquiatria 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555644/
https://www.ncbi.nlm.nih.gov/pubmed/33605397
http://dx.doi.org/10.1590/1516-4446-2020-1543

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