Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset

Kohlschütter-Tönz syndrome (KTS) manifests as neurological dysfunctions, including early-onset seizures. Mutations in the citrate transporter SLC13A5 are associated with KTS, yet their underlying mechanisms remain elusive. Here, we report that a Drosophila SLC13A5 homolog, I’m not dead yet (Indy), c...

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Detalles Bibliográficos
Autores principales: Jeong, Jiwon, Lee, Jongbin, Kim, Ji-hyung, Lim, Chunghun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555787/
https://www.ncbi.nlm.nih.gov/pubmed/34714823
http://dx.doi.org/10.1371/journal.pgen.1009871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555787/
https://www.ncbi.nlm.nih.gov/pubmed/34714823
http://dx.doi.org/10.1371/journal.pgen.1009871

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