HIV-1 propagation is highly dependent on basal levels of the restriction factor BST2

BST2 is an interferon-inducible antiviral host protein antagonized by HIV-1 Vpu that entraps nascent HIV-1 virions on the cell surface. Unexpectedly, we find that HIV-1 lacking Nef can revert to full replication competence simply by losing the ability to antagonize BST2. Using gene editing together...

Descripción completa

Detalles Bibliográficos
Autores principales: Olety, Balaji, Peters, Paul, Wu, Yuanfei, Usami, Yoshiko, Göttlinger, Heinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555903/
https://www.ncbi.nlm.nih.gov/pubmed/34714669
http://dx.doi.org/10.1126/sciadv.abj7398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555903/
https://www.ncbi.nlm.nih.gov/pubmed/34714669
http://dx.doi.org/10.1126/sciadv.abj7398

Ejemplares similares