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HIV-1 propagation is highly dependent on basal levels of the restriction factor BST2

BST2 is an interferon-inducible antiviral host protein antagonized by HIV-1 Vpu that entraps nascent HIV-1 virions on the cell surface. Unexpectedly, we find that HIV-1 lacking Nef can revert to full replication competence simply by losing the ability to antagonize BST2. Using gene editing together...

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Detalles Bibliográficos
Autores principales:	Olety, Balaji, Peters, Paul, Wu, Yuanfei, Usami, Yoshiko, Göttlinger, Heinrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555903/ https://www.ncbi.nlm.nih.gov/pubmed/34714669 http://dx.doi.org/10.1126/sciadv.abj7398

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