DCAF1-targeting microRNA-3175 activates Nrf2 signaling and inhibits dexamethasone-induced oxidative injury in human osteoblasts

Activation of nuclear-factor-E2-related factor 2 (Nrf2) signaling can protect human osteoblasts from dexamethasone-induced oxidative injury. DDB1 and CUL4 associated factor 1 (DCAF1) is a novel ubiquitin E3 ligase for Nrf2 protein degradation. We identified a novel DCAF1-targeting miRNA, miR-3175. R...

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Detalles Bibliográficos
Autores principales: Chen, Jing, Liang, Jin-qian, Zhen, Yun-Fang, Chang, Lei, Zhou, Zhen-tao, Shen, Xiong-jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556244/
https://www.ncbi.nlm.nih.gov/pubmed/34716304
http://dx.doi.org/10.1038/s41419-021-04300-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556244/
https://www.ncbi.nlm.nih.gov/pubmed/34716304
http://dx.doi.org/10.1038/s41419-021-04300-8

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