The hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein

α-Synuclein (α-Syn) can form different fibril strains with distinct polymorphs and neuropathologies, which is associated with the clinicopathological variability in synucleinopathies. How different α-syn fibril strains are produced and selected under disease conditions remains poorly understood. In...

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Detalles Bibliográficos
Autores principales: Sun, Yunpeng, Long, Houfang, Xia, Wencheng, Wang, Kun, Zhang, Xia, Sun, Bo, Cao, Qin, Zhang, Yaoyang, Dai, Bin, Li, Dan, Liu, Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556266/
https://www.ncbi.nlm.nih.gov/pubmed/34716315
http://dx.doi.org/10.1038/s41467-021-26433-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556266/
https://www.ncbi.nlm.nih.gov/pubmed/34716315
http://dx.doi.org/10.1038/s41467-021-26433-2

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