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The hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein
α-Synuclein (α-Syn) can form different fibril strains with distinct polymorphs and neuropathologies, which is associated with the clinicopathological variability in synucleinopathies. How different α-syn fibril strains are produced and selected under disease conditions remains poorly understood. In...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556266/ https://www.ncbi.nlm.nih.gov/pubmed/34716315 http://dx.doi.org/10.1038/s41467-021-26433-2 |