Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells

Ferroptosis is a form of regulated cell death that emerges to be relevant for therapy-resistant and dedifferentiating cancers. Although several lines of evidence suggest that ferroptosis is a type of autophagy-dependent cell death, the underlying molecular mechanisms remain unclear. Fin56, a type 3...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Yadong, Berleth, Niklas, Wu, Wenxian, Schlütermann, David, Deitersen, Jana, Stuhldreier, Fabian, Berning, Lena, Friedrich, Annabelle, Akgün, Seda, Mendiburo, María José, Wesselborg, Sebastian, Conrad, Marcus, Berndt, Carsten, Stork, Björn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556316/
https://www.ncbi.nlm.nih.gov/pubmed/34716292
http://dx.doi.org/10.1038/s41419-021-04306-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556316/
https://www.ncbi.nlm.nih.gov/pubmed/34716292
http://dx.doi.org/10.1038/s41419-021-04306-2

Ejemplares similares