Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia

The transcription factors PAX5, IKZF1 and EBF1 are frequently mutated in B cell acute lymphoblastic leukemia (B-ALL). We demonstrate that compound heterozygous loss of multiple genes critical for B and T cell development drives transformation, including Pax5(+/−)xEbf1(+/−), Pax5(+/−)xIkzf1(+/−) and...

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Detalles Bibliográficos
Autores principales: Heltemes-Harris, Lynn M., Hubbard, Gregory K., LaRue, Rebecca S., Munro, Sarah A., Yang, Rendong, Henzler, Christine M., Starr, Timothy K., Sarver, Aaron L., Kornblau, Steven M., Farrar, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556320/
https://www.ncbi.nlm.nih.gov/pubmed/34535769
http://dx.doi.org/10.1038/s41388-021-02012-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556320/
https://www.ncbi.nlm.nih.gov/pubmed/34535769
http://dx.doi.org/10.1038/s41388-021-02012-z

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