Targeting Plasma Kallikrein With a Novel Bicyclic Peptide Inhibitor (THR-149) Reduces Retinal Thickening in a Diabetic Rat Model

PURPOSE: To investigate the effect of plasma kallikrein (PKal)-inhibition by THR-149 on preventing key pathologies associated with diabetic macular edema (DME) in a rat model. METHODS: Following streptozotocin-induced diabetes, THR-149 or its vehicle was administered in the rat via either a single i...

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Detalles Bibliográficos
Autores principales: Van Bergen, Tine, Hu, Tjing-Tjing, Little, Karis, De Groef, Lies, Moons, Lieve, Stitt, Alan W., Vermassen, Elke, Feyen, Jean H. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2021
Materias:
Retina
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556562/
https://www.ncbi.nlm.nih.gov/pubmed/34677569
http://dx.doi.org/10.1167/iovs.62.13.18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556562/
https://www.ncbi.nlm.nih.gov/pubmed/34677569
http://dx.doi.org/10.1167/iovs.62.13.18

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