The Mpro structure-based modifications of ebselen derivatives for improved antiviral activity against SARS-CoV-2 virus

The main protease (Mpro or 3CLpro) of SARS-CoV-2 virus is a cysteine enzyme critical for viral replication and transcription, thus indicating a potential target for antiviral therapy. A recent repurposing effort has identified ebselen, a multifunctional drug candidate as an inhibitor of Mpro. Our do...

Descripción completa

Detalles Bibliográficos
Autores principales: Qiao, Zhen, Wei, Ningning, Jin, Lin, Zhang, Hongyi, Luo, Jiajie, Zhang, Yanru, Wang, KeWei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556866/
https://www.ncbi.nlm.nih.gov/pubmed/34740055
http://dx.doi.org/10.1016/j.bioorg.2021.105455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556866/
https://www.ncbi.nlm.nih.gov/pubmed/34740055
http://dx.doi.org/10.1016/j.bioorg.2021.105455

Ejemplares similares