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The Mpro structure-based modifications of ebselen derivatives for improved antiviral activity against SARS-CoV-2 virus
The main protease (Mpro or 3CLpro) of SARS-CoV-2 virus is a cysteine enzyme critical for viral replication and transcription, thus indicating a potential target for antiviral therapy. A recent repurposing effort has identified ebselen, a multifunctional drug candidate as an inhibitor of Mpro. Our do...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Published by Elsevier Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556866/ https://www.ncbi.nlm.nih.gov/pubmed/34740055 http://dx.doi.org/10.1016/j.bioorg.2021.105455 |