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Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy

Autophagy-mediated lipotoxicity plays a critical role in the progression of diabetic nephropathy (DN), but the precise mechanism is not fully understood. Whether lipophagy, a selective type of autophagy participates in renal ectopic lipid deposition (ELD) and lipotoxicity in the kidney of DN is unkn...

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Detalles Bibliográficos
Autores principales: Han, Yachun, Xiong, Shan, Zhao, Hao, Yang, Shikun, Yang, Ming, Zhu, Xuejing, Jiang, Na, Xiong, Xiaofen, Gao, Peng, Wei, Ling, Xiao, Ying, Sun, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557213/
https://www.ncbi.nlm.nih.gov/pubmed/34718329
http://dx.doi.org/10.1038/s41419-021-04326-y