Gut-derived lipopolysaccharide remodels tumoral microenvironment and synergizes with PD-L1 checkpoint blockade via TLR4/MyD88/AKT/NF-κB pathway in pancreatic cancer

Lipopolysaccharide (LPS) as an important inflammatory mediator activates the innate/adaptive immune system. The existence of LPS in pancreatic ductal adenocarcinoma (PDAC) has been reported, however, its biological function in PDAC remains unclear. Here, we demonstrated that circulating and tumoral...

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Detalles Bibliográficos
Autores principales: Yin, Hanlin, Pu, Ning, Chen, Qiangda, Zhang, Jicheng, Zhao, Guochao, Xu, Xuefeng, Wang, Dansong, Kuang, Tiantao, Jin, Dayong, Lou, Wenhui, Wu, Wenchuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557215/
https://www.ncbi.nlm.nih.gov/pubmed/34718325
http://dx.doi.org/10.1038/s41419-021-04293-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557215/
https://www.ncbi.nlm.nih.gov/pubmed/34718325
http://dx.doi.org/10.1038/s41419-021-04293-4

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