Nitric Oxide Signals Through IRAG to Inhibit TRPM4 Channels and Dilate Cerebral Arteries

Nitric oxide (NO) relaxes vascular smooth muscle cells (SMCs) and dilates blood vessels by increasing intracellular levels of cyclic guanosine monophosphate (cGMP), which stimulates the activity of cGMP-dependent protein kinase (PKG). However, the vasodilator mechanisms downstream of PKG remain inco...

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Detalles Bibliográficos
Autores principales: Ali, Sher, Solano, Alfredo Sanchez, Gonzales, Albert L, Thakore, Pratish, Krishnan, Vivek, Yamasaki, Evan, Earley, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557268/
https://www.ncbi.nlm.nih.gov/pubmed/34734188
http://dx.doi.org/10.1093/function/zqab051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557268/
https://www.ncbi.nlm.nih.gov/pubmed/34734188
http://dx.doi.org/10.1093/function/zqab051

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