The unfolded protein response in amyotrophic later sclerosis: results of a phase 2 trial

Strong evidence suggests that endoplasmic reticulum stress plays a critical role in the pathogenesis of amyotrophic lateral sclerosis (ALS) through altered regulation of proteostasis. Robust preclinical findings demonstrated that guanabenz selectively inhibits endoplasmic reticulum stress-induced eI...

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Detalles Bibliográficos
Autores principales: Dalla Bella, Eleonora, Bersano, Enrica, Antonini, Giovanni, Borghero, Giuseppe, Capasso, Margherita, Caponnetto, Claudia, Chiò, Adriano, Corbo, Massimo, Filosto, Massimiliano, Giannini, Fabio, Spataro, Rossella, Lunetta, Christian, Mandrioli, Jessica, Messina, Sonia, Monsurrò, Maria Rosaria, Mora, Gabriele, Riva, Nilo, Rizzi, Romana, Siciliano, Gabriele, Silani, Vincenzo, Simone, Isabella, Sorarù, Gianni, Tugnoli, Valeria, Verriello, Lorenzo, Volanti, Paolo, Furlan, Roberto, Nolan, John M, Abgueguen, Emmanuelle, Tramacere, Irene, Lauria, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Clinical Trial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557337/
https://www.ncbi.nlm.nih.gov/pubmed/33905493
http://dx.doi.org/10.1093/brain/awab167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557337/
https://www.ncbi.nlm.nih.gov/pubmed/33905493
http://dx.doi.org/10.1093/brain/awab167

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