Clarithromycin Inhibits Pneumolysin Production via Downregulation of ply Gene Transcription despite Autolysis Activation

Streptococcus pneumoniae, the most common cause of community-acquired pneumonia, causes severe invasive infections, including meningitis and bacteremia. The widespread use of macrolides has been reported to increase the prevalence of macrolide-resistant S. pneumoniae (MRSP), thereby leading to treat...

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Detalles Bibliográficos
Autores principales: Domon, Hisanori, Isono, Toshihito, Hiyoshi, Takumi, Tamura, Hikaru, Sasagawa, Karin, Maekawa, Tomoki, Hirayama, Satoru, Yanagihara, Katsunori, Terao, Yutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557819/
https://www.ncbi.nlm.nih.gov/pubmed/34468195
http://dx.doi.org/10.1128/Spectrum.00318-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557819/
https://www.ncbi.nlm.nih.gov/pubmed/34468195
http://dx.doi.org/10.1128/Spectrum.00318-21

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