Mutations in the Methyltransferase Motifs of L Protein Attenuate Newcastle Disease Virus by Regulating Viral Translation and Cell-to-Cell Spread

The large (L) polymerase proteins of most nonsegmented, negative-stranded (NNS) RNA viruses have conserved methyltransferase motifs, (G)-G-G-D and K-D-K-E, which are important for the stabilization and translation of mRNA. However, the function of the (G)-G-G-D and K-D-K-E motifs in the NNS RNA viru...

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Detalles Bibliográficos
Autores principales: Li, Xiao, Sun, Lu, Zhao, Jing, Tu, Kaihang, Xue, Jia, Guo, Xin, Zhang, Guozhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557825/
https://www.ncbi.nlm.nih.gov/pubmed/34585949
http://dx.doi.org/10.1128/Spectrum.01312-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557825/
https://www.ncbi.nlm.nih.gov/pubmed/34585949
http://dx.doi.org/10.1128/Spectrum.01312-21

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