Ebselen Not Only Inhibits Clostridioides difficile Toxins but Displays Redox-Associated Cellular Killing

Ebselen, a reactive organoselenium compound, was shown to inhibit toxins TcdA and TcdB by covalently binding to their cysteine protease domains. It was suggested that ebselen lacked antimicrobial activity against Clostridioides difficile. However, this perception conflicts with C. difficile having e...

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Detalles Bibliográficos
Autores principales: Marreddy, Ravi K. R., Olaitan, Abiola O., May, Jordan N., Dong, Min, Hurdle, Julian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557875/
https://www.ncbi.nlm.nih.gov/pubmed/34468187
http://dx.doi.org/10.1128/Spectrum.00448-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557875/
https://www.ncbi.nlm.nih.gov/pubmed/34468187
http://dx.doi.org/10.1128/Spectrum.00448-21

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