Beyond the Biosynthetic Gene Cluster Paradigm: Genome-Wide Coexpression Networks Connect Clustered and Unclustered Transcription Factors to Secondary Metabolic Pathways

Fungal secondary metabolites are widely used as therapeutics and are vital components of drug discovery programs. A major challenge hindering discovery of novel secondary metabolites is that the underlying pathways involved in their biosynthesis are transcriptionally silent under typical laboratory...

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Detalles Bibliográficos
Autores principales: Kwon, Min Jin, Steiniger, Charlotte, Cairns, Timothy C., Wisecaver, Jennifer H., Lind, Abigail L., Pohl, Carsten, Regner, Carmen, Rokas, Antonis, Meyer, Vera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557879/
https://www.ncbi.nlm.nih.gov/pubmed/34523946
http://dx.doi.org/10.1128/Spectrum.00898-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557879/
https://www.ncbi.nlm.nih.gov/pubmed/34523946
http://dx.doi.org/10.1128/Spectrum.00898-21

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