Drug Target Validation of the Protein Kinase AEK1, Essential for Proliferation, Host Cell Invasion, and Intracellular Replication of the Human Pathogen Trypanosoma cruzi

Protein phosphorylation is involved in several key biological roles in the complex life cycle of Trypanosoma cruzi, the etiological agent of Chagas disease, and protein kinases are potential drug targets. Here, we report that the AGC essential kinase 1 (TcAEK1) exhibits a cytosolic localization and...

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Detalles Bibliográficos
Autores principales: Chiurillo, Miguel A., Jensen, Bryan C., Docampo, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557885/
https://www.ncbi.nlm.nih.gov/pubmed/34585973
http://dx.doi.org/10.1128/Spectrum.00738-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557885/
https://www.ncbi.nlm.nih.gov/pubmed/34585973
http://dx.doi.org/10.1128/Spectrum.00738-21

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