Cargando…

Drug Target Validation of the Protein Kinase AEK1, Essential for Proliferation, Host Cell Invasion, and Intracellular Replication of the Human Pathogen Trypanosoma cruzi

Protein phosphorylation is involved in several key biological roles in the complex life cycle of Trypanosoma cruzi, the etiological agent of Chagas disease, and protein kinases are potential drug targets. Here, we report that the AGC essential kinase 1 (TcAEK1) exhibits a cytosolic localization and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chiurillo, Miguel A., Jensen, Bryan C., Docampo, Roberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557885/ https://www.ncbi.nlm.nih.gov/pubmed/34585973 http://dx.doi.org/10.1128/Spectrum.00738-21

Ejemplares similares

Mitochondrial Pyruvate Carrier Subunits Are Essential for Pyruvate-Driven Respiration, Infectivity, and Intracellular Replication of Trypanosoma cruzi
por: Negreiros, Raquel S., et al.
Publicado: (2021)

MICU1 and MICU2 Play an Essential Role in Mitochondrial Ca(2+) Uptake, Growth, and Infectivity of the Human Pathogen Trypanosoma cruzi
por: Bertolini, Mayara S., et al.
Publicado: (2019)

Functional analysis and importance for host cell infection of the Ca(2+)-conducting subunits of the mitochondrial calcium uniporter of Trypanosoma cruzi
por: Chiurillo, Miguel A., et al.
Publicado: (2019)

An Intracellular Ammonium Transporter Is Necessary for Replication, Differentiation, and Resistance to Starvation and Osmotic Stress in Trypanosoma cruzi
por: Cruz-Bustos, Teresa, et al.
Publicado: (2018)

Different Roles of Mitochondrial Calcium Uniporter Complex Subunits in Growth and Infectivity of Trypanosoma cruzi
por: Chiurillo, Miguel A., et al.
Publicado: (2017)

Deletion of a Golgi protein in Trypanosoma cruzi reveals a critical role for Mn(2+) in protein glycosylation needed for host cell invasion and intracellular replication
por: Ramakrishnan, Srinivasan, et al.
Publicado: (2021)

The long and winding road of reverse genetics in Trypanosoma cruzi
por: Chiurillo, Miguel A., et al.
Publicado: (2021)

Host–Pathogen Interaction Involved in Trypanosoma cruzi Infection
por: Castillo, Christian, et al.
Publicado: (2022)

Ablation of the P21 Gene of Trypanosoma cruzi Provides Evidence of P21 as a Mediator in the Control of Epimastigote and Intracellular Amastigote Replication
por: Teixeira, Thaise Lara, et al.
Publicado: (2022)

Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection
por: Taylor, Martin C., et al.
Publicado: (2020)

Trypanosoma cruzi Exploits Wnt Signaling Pathway to Promote Its Intracellular Replication in Macrophages
por: Volpini, Ximena, et al.
Publicado: (2018)

Stress-Induced Proliferation and Cell Cycle Plasticity of Intracellular Trypanosoma cruzi Amastigotes
por: Dumoulin, Peter C., et al.
Publicado: (2018)

Glutamine Analogues Impair Cell Proliferation, the Intracellular Cycle and Metacyclogenesis in Trypanosoma cruzi
por: Souza, Rodolpho Ornitz Oliveira, et al.
Publicado: (2020)

Lysosomal Fusion Is Essential for the Retention of Trypanosoma cruzi Inside Host Cells
por: Andrade, Luciana O., et al.
Publicado: (2004)

The Histidine Ammonia Lyase of Trypanosoma cruzi Is Involved in Acidocalcisome Alkalinization and Is Essential for Survival under Starvation Conditions
por: Mantilla, Brian S., et al.
Publicado: (2021)

Molecular and Electrophysiological Characterization of a Novel Cation Channel of Trypanosoma cruzi
por: Jimenez, Veronica, et al.
Publicado: (2012)

Astrocyte Apoptosis and HIV Replication Are Modulated in Host Cells Coinfected with Trypanosoma cruzi
por: Urquiza, Javier M., et al.
Publicado: (2017)

Trypanosoma cruzi–Host Cell Interaction
por: De Souza, Wanderley
Publicado: (2014)

Lizards as Silent Hosts of Trypanosoma cruzi
por: Botto-Mahan, Carezza, et al.
Publicado: (2022)

Silencing cytokeratin 18 gene inhibits intracellular replication of Trypanosoma cruzi in HeLa cells but not binding and invasion of trypanosomes
por: Claser, Carla, et al.
Publicado: (2008)

Modulation of host central carbon metabolism and in situ glucose uptake by intracellular Trypanosoma cruzi amastigotes
por: Shah-Simpson, Sheena, et al.
Publicado: (2017)

Review on Trypanosoma cruzi: Host Cell Interaction
por: de Souza, Wanderley, et al.
Publicado: (2010)

Trypanosoma cruzi Infection and Host Lipid Metabolism
por: Miao, Qianqian, et al.
Publicado: (2014)

Identification of Contractile Vacuole Proteins in Trypanosoma cruzi
por: Ulrich, Paul N., et al.
Publicado: (2011)

Trypanosoma cruzi: mechanism of entry and intracellular fate in mammalian cells
Publicado: (1976)

The Intracellular Amastigote of Trypanosoma cruzi Maintains an Actively Beating Flagellum
por: Won, Madalyn M., et al.
Publicado: (2023)

Depletion of Host Cell Focal Adhesion Kinase Increases the Susceptibility to Invasion by Trypanosoma cruzi Metacyclic Forms
por: Onofre, Thiago Souza, et al.
Publicado: (2019)

Trypanosoma cruzi Utilizes the Host Low Density Lipoprotein Receptor in Invasion
por: Nagajyothi, Fnu, et al.
Publicado: (2011)

A CRISPR/Cas9-riboswitch-Based Method for Downregulation of Gene Expression in Trypanosoma cruzi
por: Lander, Noelia, et al.
Publicado: (2020)

Transcriptome Remodeling in Trypanosoma cruzi and Human Cells during Intracellular Infection
por: Li, Yuan, et al.
Publicado: (2016)

Nanocarrier-enhanced intracellular delivery of benznidazole for treatment of Trypanosoma cruzi infection
por: Li, Xiaomo, et al.
Publicado: (2021)

Trypanosoma cruzi: adaptation to its vectors and its hosts
por: Noireau, François, et al.
Publicado: (2009)

Impact of Laboratory-Adapted Intracellular Trypanosoma cruzi Strains on the Activity Profiles of Compounds with Anti-T. cruzi Activity
por: Sykes, Melissa L., et al.
Publicado: (2023)

Aurora kinase protein family in Trypanosoma cruzi: Novel role of an AUK-B homologue in kinetoplast replication
por: Fassolari, Matías, et al.
Publicado: (2019)

Trypanosoma cruzi Evades the Complement System as an Efficient Strategy to Survive in the Mammalian Host: The Specific Roles of Host/Parasite Molecules and Trypanosoma cruzi Calreticulin
por: Ramírez-Toloza, Galia, et al.
Publicado: (2017)

Investigation of pyrimidine nucleoside analogues as chemical probes to assess compound effects on the proliferation of Trypanosoma cruzi intracellular parasites
por: Sykes, Melissa Louise, et al.
Publicado: (2020)

Identification of inhibitors for the transmembrane Trypanosoma cruzi eIF2α kinase relevant for parasite proliferation
por: Marcelino, Tiago de Paula, et al.
Publicado: (2023)

Successful invasion of Trypanosoma cruzi trypomastigotes is dependent on host cell actin cytoskeleton
por: Bonifácio, Bruno Souza, et al.
Publicado: (2022)

Unique behavior of Trypanosoma cruzi mevalonate kinase: A conserved glycosomal enzyme involved in host cell invasion and signaling
por: Ferreira, Éden Ramalho, et al.
Publicado: (2016)

Replication origin location might contribute to genetic variability in Trypanosoma cruzi
por: de Araujo, Christiane Bezerra, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_k7bcqc6nml47nrq7j42gdidnao