A New Thienopyrimidinone Chemotype Shows Multistage Activity against Plasmodium falciparum, Including Artemisinin-Resistant Parasites

Human malaria infection begins with a one-time asymptomatic liver stage followed by a cyclic symptomatic blood stage. For decades, the research for novel antimalarials focused on the high-throughput screening of molecules that only targeted the asexual blood stages. In a search for new effective com...

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Detalles Bibliográficos
Autores principales: Bosson-Vanga, Henriette, Primas, Nicolas, Franetich, Jean-François, Lavazec, Catherine, Gomez, Lina, Ashraf, Kutub, Tefit, Maurel, Soulard, Valérie, Dereuddre-Bosquet, Nathalie, Le Grand, Roger, Donnette, Mélanie, Mustière, Romain, Amanzougaghene, Nadia, Tajeri, Shahin, Suzanne, Peggy, Malzert-Fréon, Aurélie, Rault, Sylvain, Vanelle, Patrice, Hutter, Sébastien, Cohen, Anita, Snounou, Georges, Roques, Pierre, Azas, Nadine, Lagardère, Prisca, Lisowski, Vincent, Masurier, Nicolas, Nguyen, Michel, Paloque, Lucie, Benoit-Vical, Françoise, Verhaeghe, Pierre, Mazier, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557901/
https://www.ncbi.nlm.nih.gov/pubmed/34724729
http://dx.doi.org/10.1128/Spectrum.00274-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557901/
https://www.ncbi.nlm.nih.gov/pubmed/34724729
http://dx.doi.org/10.1128/Spectrum.00274-21

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