Adaptation to Fluconazole via Aneuploidy Enables Cross-Adaptation to Amphotericin B and Flucytosine in Cryptococcus neoformans

The high morbidity and mortality of cryptococcal meningitis is due to the limited range of therapeutic options: only three classes of antifungal drugs are available (polyenes [amphotericin B], azoles [fluconazole], and pyrimidine analogues [flucytosine]). Fluconazole is the most widely used antifung...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Feng, Gritsenko, Vladimir, Lu, Hui, Zhen, Cheng, Gao, Lu, Berman, Judith, Jiang, Yuan-ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557924/
https://www.ncbi.nlm.nih.gov/pubmed/34585947
http://dx.doi.org/10.1128/Spectrum.00723-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557924/
https://www.ncbi.nlm.nih.gov/pubmed/34585947
http://dx.doi.org/10.1128/Spectrum.00723-21

Ejemplares similares