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Adaptation to Fluconazole via Aneuploidy Enables Cross-Adaptation to Amphotericin B and Flucytosine in Cryptococcus neoformans

The high morbidity and mortality of cryptococcal meningitis is due to the limited range of therapeutic options: only three classes of antifungal drugs are available (polyenes [amphotericin B], azoles [fluconazole], and pyrimidine analogues [flucytosine]). Fluconazole is the most widely used antifung...

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Detalles Bibliográficos
Autores principales:	Yang, Feng, Gritsenko, Vladimir, Lu, Hui, Zhen, Cheng, Gao, Lu, Berman, Judith, Jiang, Yuan-ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557924/ https://www.ncbi.nlm.nih.gov/pubmed/34585947 http://dx.doi.org/10.1128/Spectrum.00723-21

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