Validation and invalidation of SARS-CoV-2 main protease inhibitors using the Flip-GFP and Protease-Glo luciferase assays

SARS-CoV-2 main protease (M(pro)) is one of the most extensively exploited drug targets for COVID-19. Structurally disparate compounds have been reported as M(pro) inhibitors, raising the question of their target specificity. To elucidate the target specificity and the cellular target engagement of...

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Detalles Bibliográficos
Autores principales: Ma, Chunlong, Tan, Haozhou, Choza, Juliana, Wang, Yuyin, Wang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558150/
https://www.ncbi.nlm.nih.gov/pubmed/34745850
http://dx.doi.org/10.1016/j.apsb.2021.10.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558150/
https://www.ncbi.nlm.nih.gov/pubmed/34745850
http://dx.doi.org/10.1016/j.apsb.2021.10.026

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