Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma

Despite a general role for the HIF hydroxylase system in cellular oxygen sensing and tumour hypoxia, cancer-associated mutations of genes in this pathway, including PHD2, PHD1, EPAS1 (encoding HIF-2α) are highly tissue-restricted, being observed in pseudohypoxic pheochromocytoma and paraganglioma (P...

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Detalles Bibliográficos
Autores principales: Eckardt, Luise, Prange-Barczynska, Maria, Hodson, Emma J, Fielding, James W, Cheng, Xiaotong, Lima, Joanna D C C, Kurlekar, Samvid, Douglas, Gillian, Ratcliffe, Peter J, Bishop, Tammie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558849/
https://www.ncbi.nlm.nih.gov/pubmed/34658364
http://dx.doi.org/10.1530/ERC-21-0211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558849/
https://www.ncbi.nlm.nih.gov/pubmed/34658364
http://dx.doi.org/10.1530/ERC-21-0211

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