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Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma

Despite a general role for the HIF hydroxylase system in cellular oxygen sensing and tumour hypoxia, cancer-associated mutations of genes in this pathway, including PHD2, PHD1, EPAS1 (encoding HIF-2α) are highly tissue-restricted, being observed in pseudohypoxic pheochromocytoma and paraganglioma (P...

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Detalles Bibliográficos
Autores principales:	Eckardt, Luise, Prange-Barczynska, Maria, Hodson, Emma J, Fielding, James W, Cheng, Xiaotong, Lima, Joanna D C C, Kurlekar, Samvid, Douglas, Gillian, Ratcliffe, Peter J, Bishop, Tammie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558849/ https://www.ncbi.nlm.nih.gov/pubmed/34658364 http://dx.doi.org/10.1530/ERC-21-0211

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